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This study will determine the effectiveness of the oral steroid prednisone in decreasing pain and improving function in people with sciatica. The primary objective is to measure the effects of oral prednisone on sciatic nerve function using a new, small group of people with sciatica. Additionally, we will investigate how oral prednisone affects function and pain tolerance in those with the same symptoms.Key Words:Prednisone, SciaticaIntroductionPatients with chronic sciatica report a range of chronic issues, such as:Pained, reduced muscle tonePleased sensation during exerciseLow physical performance, such as poor muscular strength/power and decreased sports performanceProlonged fatigueThe purpose of this study was to investigate the efficacy of oral prednisone to treat pain and sciatic nerve dysfunction in people with chronic sciatica who have not previously received prescribed analgesic treatments.SubjectsThirty-three people (mean age 47.7 years; range 21-80 years) were selected, all healthy. Of those selected, seven were current long-term steroid users before surgery and 14 were currently off use of steroid.All participants answered a clinical research questionnaires and self-reported their pain severity on a number of occasions during the last year. To determine baseline prednisone status, participants answered questions on both the use of oral steroids and their history of previous oral steroid use before diagnosis of Sciatica with sciatic nerve dysfunction.Study DesignThis analysis of 3-month, randomized, double-blind, placebo controlled trials will examine the effects of oral prednisone injections on sciatic nerve function.Patients will be randomized in the main trial to 4 consecutive injections of 2.4 mg of oral prednisone (a dose which was chosen in some instances to reduce side-effects) or placebos. A similar design to that of the short-term trial will be used in the long-term follow-up for participants who are not currently receiving oral steroid therapy.Participants are to remain in a comfortable chair at least 12 hours after the last injection to allow the systemic exposure of oral prednisone.Patients in the main trial will receive their prednisone in two 1-month cycles, during which they will receive an injection at week 1 and a follow-up injection at week 18. There will be no additional injections to assess drug efficacy.The primary objective of this study is to measure the effects of oral prednisone on sciatic nerve function using a new,Similar articles: